| Compound Code | KAT-DNRI-03 |
| Pharmacological Tag | Central stimulant (non-amphetamine) |
| Structural Class | Diphenylmethyl morpholine |
| Mechanism (Putative) |
DAT inhibition → ↑ dopamine
NET inhibition → ↑ norepinephrine
SERT inactivity → no serotonergic burden
|
| Functional Role |
Cognitive excitation
Wake-state extension
Appetite suppression
|
| Structural Analogues |
Desoxypipradrol (2-DPMP)
Diphenylprolinol (D2PM)
Pipradrol
|
| Predicted Onset | Delayed (lipophilic, non-ionizable) |
| Predicted Duration | Extended (>12 hours) |
| Affinity Profile |
DAT > NET >> SERT
|
| Computational Predictions |
CNS Activity: high
DAT Potency: sub-150 nM
BBB Penetration: positive
hERG Inhibition: unlikely
Mutagenicity: low
Metabolism: benzylic hydroxylation, N-dealkylation
|
| Interpretation |
An alternative neurostimulant vector
Non-classical dopamine modulation
Designed for vigilance without excess
Theoretical scaffold for cognitive extension
|