Compound Code | KAT–AMPH–05 |
Pharmacological Tag | Central stimulant / anorexiant |
Structural Class | Biphenyl-substituted amphetamine |
Mechanism (Putative) |
Monoamine releasing agent
↑ dopamine (via TAAR1 + DAT reversal)
↑ norepinephrine
Possible serotonergic modulation (5-HT₂ family)
|
Functional Role |
Anorexiant stimulant
Cognitive energizer
Hypothalamic appetite suppression
|
Structural Analogues |
Phentermine
4-methylamphetamine
Fenfluramine (partial comparison)
Methamphetamine (core backbone)
|
Predicted Onset | Moderate–fast (lipophilic + protonatable) |
Predicted Duration | Intermediate (4–8h range) |
Affinity Profile |
TAAR1 agonism → monoamine release
DAT/NET/SERT transporter reversal
Weak receptor binding; high transporter interaction
|
Computational Predictions |
CNS Penetration: strong
Transporter activity: high reversal potential
5-HT2C modulation: possible
hERG: low interference
Reactive metabolites: unlikely
Metabolic routes: N-deamination, hydroxylation of distal ring
|
Interpretation |
Designed anorexiant with dopaminergic backbone
Phenylethylamine energy vector with biphenyl load
Weight-loss adjacent
Speculative hybrid between pharmacological nostalgia and metabolic control
|