Biphenylamphetamine

Compound CodeKAT–AMPH–05
Pharmacological TagCentral stimulant / anorexiant
Structural ClassBiphenyl-substituted amphetamine
Mechanism (Putative) Monoamine releasing agent ↑ dopamine (via TAAR1 + DAT reversal) ↑ norepinephrine Possible serotonergic modulation (5-HT₂ family)
Functional Role Anorexiant stimulant Cognitive energizer Hypothalamic appetite suppression
Structural Analogues Phentermine 4-methylamphetamine Fenfluramine (partial comparison) Methamphetamine (core backbone)
Predicted OnsetModerate–fast (lipophilic + protonatable)
Predicted DurationIntermediate (4–8h range)
Affinity Profile TAAR1 agonism → monoamine release DAT/NET/SERT transporter reversal Weak receptor binding; high transporter interaction
Computational Predictions CNS Penetration: strong Transporter activity: high reversal potential 5-HT2C modulation: possible hERG: low interference Reactive metabolites: unlikely Metabolic routes: N-deamination, hydroxylation of distal ring
Interpretation Designed anorexiant with dopaminergic backbone Phenylethylamine energy vector with biphenyl load Weight-loss adjacent Speculative hybrid between pharmacological nostalgia and metabolic control