PHENFORMIN
Chemical Structure phenformin structure
Drug Class Biguanide antidiabetic agent (withdrawn)
Mechanisms of Action Potent mitochondrial complex I inhibitor. Lowers ATP, AMP -> AMPK activation.
Inhibits hepatic gluconeogenesis; reduces insulin resistance.
Shows selective toxicity in metabolically active tumor cells via ROS induction and metabolic stress.
Monograph Chemical Name: 2-(Phenethylbiguanide)
Development: Introduced in the 1950s; withdrawn by 1978.
Exhibited strong antidiabetic effect, but linked to lactic acidosis (~1 in 4,000 incidence).
Lipophilic; accumulates in mitochondria; metabolized by CYP2D6.
Modern Interest: Being re-evaluated as an anti-cancer compound with high mitochondrial selectivity.
Represents a pharmacologically potent but clinically hazardous molecule. A high-risk, high-concept compound of enduring interest.

Full Monograph.
Synthesis batch initiated 1 g target
|Amount acquired for synthesis: 2 g
|Amount acquired for speculative holding: 0 mg
Note: These figures reflect total documented acquisitions. Updated manually
OrderBook

Offer

  • 250mg x 4 @ 25 EUR
  • 100mg x 5 @ 20 EUR
  • 100mg x 5 @ 10 EUR

Bid

  • No Bids
Order via (ONLY TO EUROPE, EXCEPT UK, DENMARK, GERMANY AND AUSTRIA.)

⧉ BUY CONTRACTS

⧉ SELL CONTRACTS